We have been commonly asked about the impact of Visikol HISTO on fluorescent proteins (FP) in tissues. Unfortunately, the Visikol HISTO approach will quench FP in tissues over time. To visualize FP in tissue it is suggested that anti-FP immunolabels are utilized. While this process will increase overall tissue processing time, it will increase the signal of FP and allow for improved imaging results. We are currently working on alternative FP compatible tissue clearing techniques and will update you on our progress on that research once we have some updates.