Q1 Quarterly Review

Building Visikol continues to be an amazingly fun, challenging, and rewarding endeavor. Every morning, I find myself checking my email right away to see what feedback we have gotten from our customers, and what complex research problems researchers are using our products to investigate. This feedback continually reminds me of why we launched Visikol in the first place – to accelerate innovation and to allow researchers to ask and answer new questions.

Over the last few months we have celebrated many firsts – On February 24th we celebrated our first anniversary as Visikol, Inc. and in January we brought on our first new team member: Dr. Graeme Gardner from Rutgers University. We are thrilled by the progress that we have made so far and are excited to continue to grow the company:

Visikol HISTO Progress:

To date, 300 research labs in 30 countries have used Visikol HISTO, and the feedback that we have received so far has been just fantastic. Bringing an enabling technology into the marketplace is a challenging process fraught with many roadblocks. Through beta-testing Visikol HISTO with researchers in new applications and soliciting feedback, we have been able to uncover these roadblocks and find strategies to mitigate them. To help our users get the most out of Visikol, we continually update and improve our product guidance with all the feedback received from researchers. If you are interested in learning more, please see our updated Visikol HISTO Guidebook.

Visikol TOX Progress:

Of all of the things that we have completed thus far, I am most proud of the Visikol TOX product for developmental and reproductive toxicology studies. Since inventing Visikol TOX in 2014, we have turned it into a valuable bio-imaging platform that not only accelerates the drug discovery process, but also reduces the number of animals required in toxicology studies. Visikol TOX represents to me the great synergies of our team as Tom, Nick, and I all worked on different components that came together to create a valuable and highly impactful platform.

Grant Progress:

Our team has absolutely no shortage of great ideas and we find ourselves continually submitting grants for new applications of the Visikol HISTO technology as well as other novel bio-imaging ideas. We are very fortunate that there are programs like the NIH and NSF small business innovation research grants (SBIR) that fund innovative and cutting edge technology development. In December and January we submitted for six Phase I SBIR grants with collaborators and expect to hear back on most of these grants in the near future. We are optimistic about these projects as we have teamed up with some great collaborators! We also submitted our Phase II NSF SBIR after the successful completion of our NSF Phase I project, and are very excited at the prospect of continuing our NSF funded research. Our goal for 2017 is to further expand our R&D efforts through the use of SBIR grants, and we have placed significant time and effort on these. Since launching Visikol we have submitted thirteen, been rejected from five, been awarded one, and are waiting to hear back on seven.

Things to come:

In the next few months you will see significant developments from our team around Visikol HISTO assays for spheroid visualization. Drug discovery is undergoing a paradigm shift where in-vitro work is moving from 2-D cell based assays to 3D cell based assays as they more accurately depict in-vivo tissues. However, researchers are still using 2D (histology) and 1D assays (total ATP) to evaluate these 3D spheroids, ignoring the spatial features that make them intrinsically more valuable than 2D cell cultures. We are developing 3D assays for spheroids that will allow researchers to move beyond traditional endpoints (IC50) and towards evaluating the spatial heterogeneity of spheroids. For example, we will enable companies to understand where their antibodies are targeting within tumors (necrotic core, periphery) and the type of cell these drugs target.

As we are now gaining traction in the marketplace with Visikol HISTO and Visikol TOX, our focus is shifting from pure research and development, to commercialization and the application of the Visikol HISTO platform to several areas including spheroids. We are excited to apply the Visikol HISTO technology to new problems and will be shifting to spending considerable resources on commercialization in the second half of the year.

I look forward to sharing more great news with you in Q2! Thanks for following our progress.

-Michael