Antibodies Validated for IMC2022-10-12T12:48:35-05:00

Below is a list of antibodies which have been validated for use in IMC using Maxpar® OnDemand Antibodies. If your antibody is not on this list, it can be easily conjugated using a MaxPar custom conjugation kit to build your panel of interest. We routinely work with clients to develop custom panels to ensure that we best meet their multiplex tissue imaging needs.

TargetTissue TypeReported Reactivity
CD98FFPEHuman
Alpha-Smooth Muscle Actin FFPE, FrozenHuman, Mouse 
Anti-B-actinFFPECross, Human, Mouse
Arginase-1FFPECross, Human
aSMA  (1A4)FFPE, FrozenHuman, Mouse
B7-H4FFPEHuman
BCL-2FFPEHuman, Mouse
BCL-6FFPEHuman, Mouse
Beta TubulinFFPECross, Human, Mouse
Beta-CateninFFPEHuman, Mouse, Rat
BRCA1FFPEHuman, Mouse
Caspase-3 cleavedFFPECross, Human
CD107a/LAMP1FFPEHuman
CD11bFFPEHuman, Mouse
CD11cFrozenCross, Human
CD127FFPECross, Human, Mouse
CD134FFPEHuman, Mouse
CD14FFPEHuman, Mouse
CD15FFPE, FrozenHuman
CD16FFPE, FrozenHuman
CD16 FFPE, FrozenHuman, Rat 
CD163FFPE, FrozenHuman
CD163 FFPE, FrozenHuman 
CD19FFPECross, Human
CD194/CCR4FFPEHuman
CD196 (CCR6)FrozenCross, Human
CD20FrozenCross, Human
CD20 FFPEHuman 
CD223/LAG3FFPEHuman
CD227/Mucin 1FFPEHuman
CD235abFFPEHuman
CD25FFPEHuman
CD27FrozenHuman
CD274/PD-L1FFPE, FrozenHuman
CD276/B7-H3FFPEHuman
CD278/ICOSFFPEHuman
CD279/PD-1FrozenCross, Human
CD28FrozenHuman
CD3FFPEHuman, Mouse
CD31FrozenCross, Human
CD31 FFPEHuman, Mouse, Rat
CD326 (EpCAM)FFPE, FrozenHuman
CD366/TIMFFPEHuman, Mouse
CD38FrozenCross, Human
CD4FrozenCross, Human
CD4 FFPEMouse
CD44FFPE, FrozenHuman, Mouse
CD45FFPE, FrozenHuman
CD45 FFPEMouse
CD45R/B220FFPEHuman, Mouse
CD45RAFFPE, FrozenCross, Human
CD45ROFFPE, FrozenCross, Human
CD45RO FFPE, FrozenHuman, Monkey, Rhesus, Chimpanzee
CD57FFPEHuman 
CD63FFPEHuman
CD66aFFPEHuman
CD66bFFPEHuman
CD68FFPE, FrozenHuman
CD68 FFPE, FrozenHuman 
CD73FFPEHuman
CD74FFPEHuman, Mouse
CD8 FFPEMouse
CD86FrozenCross, Human
CD8AFrozenCross, Human
CD8a FFPEHuman 
C-Myc p67FFPEHuman
Collagen IFFPE, FrozenHuman, Mouse
CytokeratinFFPECross, Human, Mouse
E-CadherinFFPE, FrozenCross, Human, Mouse
EGFRFFPECross, Human
EpCAMFFPEHuman, Mouse, Rat
F4/80 FFPEMouse
FibronectinFFPEHuman, Mouse, Rat
FoxP3 FFPEMouse, Bovine, Dog, Cat, Pig, Rat
Granzyme B FFPEHuman, Mouse, Rat
Histone H3 FFPEHuman, Mouse, Rat,
HLA-ABCFrozenCross, Human
HLA-DR FFPE, FrozenHuman, Rhesus 
IDOFFPEHuman
IgMFrozenCross, Human
iNOS FFPEHuman, Mouse
Keratin 8/18FFPEHuman
Ki-67FFPE, FrozenCross, Human, Mouse
Ly-6GFFPEMouse
MetFFPEHuman, Mouse
MHC Class IIFFPEMouse
p53FFPEHuman
Pan-CKFFPE, FrozenCross, Human, Mouse
Pan-ActinFFPEHuman, Mouse
Pan-KeratinFFPEHuman
PD-1FFPEHuman
PD-L1FFPEHuman
PD-L2FFPEHuman
PerforinFrozenCross, Human
pERK1/2 [T202/Y204] FFPEHuman, Mouse, Rat
pH2AX [S139]FFPEHuman, Mouse
pHistone H3 [Ser28]FFPECross, Human
Phospho-FFPECross, Human, Mouse
Phospho-4EBP1FFPECross, Human, Mouse
Phospho-CREB [Ser133]FFPECross, Human, Mouse
Phosphop44/42 MAPKFFPEHuman, Mouse
Phospho-Stat3FFPEHuman
p-NF-kBp65FFPEHuman, Mouse
pS6FFPEHuman, Mouse
SOX-9FFPECross, Human, Mouse
SykFFPEHuman
T-betFFPEHuman
VEGFFFPEHuman
Vimentin FFPE, FrozenHuman, Mouse, Rat, Rabbit, Bovine, Canine, Hamster, Monkey, Cross
VistaFFPEHuman

17-plex IMC Panel

We also have several pre-built panels, such as the 17-plex IMC panel described below.

The 17-plex panel for IMC combines 3 panels together to assess the complexities of
the immune landscape within the tumor microenvironment.

Human Tissue Architecture Panel

Enables staining of tissue architecture,
including stroma, epithelial tissue,
and vasculature.

  • Alpha-smooth muscle actin
  • Collage type I
  • E-cadherin
  • Histone H3
  • Vimentin

Human Tumor Infiltrating Lymphocytes Panel

Enables staining of epithelial cells; phenotyping of T cells (helper, cytotoxic, memory, and regulatory), B cells, and monocytes/macrophages; and identification of potential CD68+ tumor cells.

  • CD20
  • CD3
  • CD4
  • CD45RO
  • CD68
  • CD8a
  • FoxP3
  • Pan-keratin

Human Immune
Activation
Panel

Allows for the phenotyping of
activated T cells.

  • Granzyme B
  • Ki-67
  • PD-1
  • PD-L1

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