Cytotoxicity-Hepatotoxicity Screen DILItrain™2021-10-14T13:17:52-05:00

Hepatotoxicity Screen (DILItrain™)

Our cytotoxicity and hepatotoxicity screening service makes early, high-acuity assessment of hepatotoxic risk cost-effective for smaller organizations and thereby brings new illumination to the challenge of reducing late-stage candidate attrition.  The cytotoxicity and hepatotoxicity results are generated on HUREL® micro livers, which in peer-reviewed studies have been shown to provide predictive sensitivity and accuracy superior to that of both 3D spheroidal primary hepatocyte cultures and hepatoma cell lines.

Protocol

14-day repeat-dosing protocol with ATP readout on Days 2 and 14.

Models Available

All HUREL micro liver models

Study Turnaround Time

Receipt of sample to data delivery, is 21 days

Price

$975 per compound

Application

Early lead selection stage of preclinical discovery/development—i.e., at roughly the same time as such other basic panels as solubility and Herg assays—so as to minimize the production burden on synthetic chemistry.

request quote

This website uses cookies to enhance the user experience. Ok