HUREL® Micro Liver Services2021-11-17T14:31:13-05:00

Services

Visikol leverages the HUREL micro liver models to provide its clients with a suite of best-in-class liver in vitro assays.

Multi-Parameter Toxicity

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Our Multi-Parameter Toxicity assay’s apply HUREL’s superior metabolic competency to a panel of complementary assays, creating a multi-parametric characterization of hepatotoxic risk.  HUREL Tox™  incorporates a 14-day, repeat-dose cytotoxicity study with both ATP and albumin (ELISA) readouts.

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Cytotoxicity and Hepatotoxicity Screening

Our cytotoxicity and hepatotoxicity screening service makes early, high-acuity assessment of hepatotoxic risk cost-effective for smaller organizations and thereby brings new illumination to the challenge of reducing late-stage candidate attrition.

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Metabolite Generation and ID

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HUREL micro livers produce robust metabolite yields that closely correlate to metabolites generated by parent compounds in vivo.

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Metabolic Clearance

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The HUREL micro liver coculture system is a robust and reliable method for human in vivo clearance prediction and metabolite detection of slowly metabolized drugs.

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Viral Liver Disease Modeling

The HUREL Viral™ platform aids the study of viral persistence and accelerates the development of antiviral drugs not just to mitigate recurring symptoms of but to fully cure chronic hepatitis B (HBV).

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HUREL® Flux™

Hepatobiliary research services based on a new, patent-pending efflux transporter assay method.  Visikol’s HUREL primary hepatocyte co-cultures allow the hepatocytes to polarize and form stable and enduring biliary canaliculi networks and their associated transporters for over 30 days.

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