Hepatobiliary research services based on a new, patent-pending efflux transporter assay method. Transporters can play an important role in the clearance and excretion of the parent drug and/or its metabolite(s) into the bile canaliculus. In-vitro methods for accurately predicting such dispositions are of great need.
Visikol’s HUREL primary hepatocyte co-cultures allow the hepatocytes to polarize and form stable and enduring biliary canaliculi networks and their associated transporters for over 30 days.
HUREL® Flux™ is cost-effective and available in a variety of species including human, monkey, dog, and rat.
HUREL® Flux™ Features:
- Efflux transport channel inhibition
- Biliary clearance
- Direct mass spec measurement
- No radio-or fluorescent labeling required
HUREL® Flux™ Assay Method