Hepatotoxicity Screen (DILItrain™)
Our cytotoxicity and hepatotoxicity screening service makes early, high-acuity assessment of hepatotoxic risk cost-effective and thereby brings new illumination to the challenge of reducing late-stage candidate attrition. The cytotoxicity and hepatotoxicity results are generated on HUREL® micro livers, which in peer-reviewed studies have been shown to provide predictive sensitivity and accuracy superior to that of both 3D spheroidal primary hepatocyte cultures and hepatoma cell lines.
14-day repeat-dosing protocol with ATP readout on Days 2 and 14.
Study Turnaround Time
Receipt of sample to data delivery, is 21 days
Early lead selection stage of preclinical discovery/development—i.e., at roughly the same time as such other basic panels as solubility and Herg assays—so as to minimize the production burden on synthetic chemistry.