Enhance Your Drug Discovery and Development with Precision-Cut Liver Slices
Ex vivo assay services using liver tissue from healthy or diseased human tissues are the closest thing to a clinical study.
A major hurdle in any drug discovery program is finding reliable and cost-effective assays to screen compounds prior to clinical studies. This is especially important for therapeutic areas for which animal models poorly translate into clinical results. Liver disease represents a major unmet medical need in western countries. Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, affecting nearly one quarter of the population in the US. In 50% of patients, NAFLD can progress to non-alcoholic steatohepatatitis (NASH), an inflammatory syndrome which disrupts hepatic function. There are currently no approved treatments for NAFLD or NASH, and considerable resources are currently being expended to address these syndromes.
There exists a significant translation gap between the in vitro and animal models used to assess new molecular entities targeting liver disease and clinical results due to the complex interplay of the numerous etiologies of liver dysfunction and the difficulty in replicating the disease pathology effectively in a model for screening purposes. Utilizing primary tissue obtained directly from human donors, precision-cut liver slices (PCLS) offer unique advantages from a drug discovery standpoint.
Precision-cut liver slices are the most powerful model to screen compounds for efficacy in treating liver disease prior to a clinical trial.
Utilizing primary human tissues, the interrogation of the exact disease state of interest with your compounds is possible, so you can have confidence your results will translate to the clinic.
High Value Endpoints
Using slide scanning, high content confocal imaging, qPCR, and ELISA, a single study can capture a large number of valuable endpoints, giving you more data about your compounds.
Our expert team processes images and analyzes data, delivering actionable insights in an easy-to-read report, so you can make decisions and push forward your drug discovery efforts.
How it works
Precision-cut tissues of any kind
Many tissue types are amenable to precision-cut studies, from human or animal donors. Please contact us to discuss utilizing other tissue types in a precision-cut tissue slice assay format.