Retinal Labeling and Imaging for Gene Therapies
Eyesight naturally declines as we age, though research shows more than 2 million people worldwide are affected by blindness [...]
Cell Viability and Cytotoxicity Assessment
When Pharmaceutical companies are developing new therapeutics, it is essential to test the viability and cytotoxicity of those compounds [...]
Using Cell Painting for Morphological Changes
To understand the cytological profiles of cells, a cell painting assay can be used to identify the difference in [...]
Methods of Drug Delivery
Any compound that is a part of the drug discovery process must be assessed for its suitability for [...]
Gene-specific methylation analysis by LC-MS/MS
DNA methylation is a critical epigenetic modification that controls gene expression and genome stability, which has oncogenic implications during [...]
Combining Cell Painting and Antibody Labeling
The cell painting assay is a high-content image-based method for morphological profiling using fluorescent dyes. These dyes reveal relevant [...]
Working with Spheroids: Challenges, Limitations and Effectiveness
When working on drug discovery and assay development, scientists often use models that can help mimic the effects of [...]
Using HUREL Micro Livers to Study Metabolization of Compounds
A majority of pharmaceutical compounds are delivered orally, as the ease of use of an oral medication makes it [...]
The Importance of IC50 Determination
The pharmaceutical industry relies on the products it develops. A major factor that heavily affects the success of these [...]
The Role of Effective Project Management in Contract Research
On average it takes 10 years to bring a drug to market. In many cases a decade is long [...]