Cell Viability and Cytotoxicity Assessment
Carol Tomaszewski2022-09-20T10:40:53-05:00When Pharmaceutical companies are developing new therapeutics, it is essential to test the viability and cytotoxicity of those compounds [...]
Using Cell Painting for Morphological Changes
Carol Tomaszewski2022-09-02T07:24:24-05:00To understand the cytological profiles of cells, a cell painting assay can be used to identify the difference in [...]
Methods of Drug Delivery
Carol Tomaszewski2022-08-17T09:33:56-05:00Any compound that is a part of the drug discovery process must be assessed for its suitability for [...]
Gene-specific methylation analysis by LC-MS/MS
Carol Tomaszewski2022-08-04T13:56:00-05:00DNA methylation is a critical epigenetic modification that controls gene expression and genome stability, which has oncogenic implications during [...]
Combining Cell Painting and Antibody Labeling
Carol Tomaszewski2022-07-29T05:58:55-05:00The cell painting assay is a high-content image-based method for morphological profiling using fluorescent dyes. These dyes reveal relevant [...]
Working with Spheroids: Challenges, Limitations and Effectiveness
Carol Tomaszewski2022-07-19T07:52:03-05:00When working on drug discovery and assay development, scientists often use models that can help mimic the effects of [...]
Using HUREL Micro Livers to Study Metabolization of Compounds
Carol Tomaszewski2022-07-13T07:48:19-05:00A majority of pharmaceutical compounds are delivered orally, as the ease of use of an oral medication makes it [...]
The Importance of IC50 Determination
Carol Tomaszewski2022-06-07T08:59:27-05:00The pharmaceutical industry relies on the products it develops. A major factor that heavily affects the success of these [...]
The Role of Effective Project Management in Contract Research
Carol Tomaszewski2022-03-23T11:59:13-05:00On average it takes 10 years to bring a drug to market. In many cases a decade is long [...]
Feature Selection for Drug Discovery
Carol Tomaszewski2022-03-14T08:25:29-05:00When it comes to drug discovery, the mechanism of action for a treatment is sometimes poorly understood or not [...]