The HCR imaging platform opens a new era for ISH and IHC, enabling multiplexed, quantitative, enzyme-free labeling of biomolecules in any sample type regardless of thickness or preparation. HCR RNA-FISH and HCR IHC allow simultaneous detection of up to 10 RNA and protein targets, respectively. Through this unique partnership, HCR RNA-FISH can be combined with Visikol’s wide array of in-house validated multiplex immunohistochemistry panels. This enables high-resolution co-detection of RNA and protein molecules with spatiotemporal and functional context in tissues. Furthermore, the technique is compatible with thick whole mount tissues in tandem with tissue clearing such that RNA can be imaged in large intact tissues using confocal or light sheet microscopy.