Plant Biology

General clearing agent for plant tissues

Skeletal Visualization

Improved skeletal visualization for DART studies

3D Histology

Adding a third dimension to histology

 

Gross Visualization

Clearing for gross visualization of animal tissues

Optical CT

Optical computed tomography with Clara

 

Whole tissue optical imaging with Visikol

Immunohistochemistry

Visikol® enables whole mount immuno-histochemistry (IHC) like never before. Obtain whole-tissue protein maps using whole mount IHC followed by clearing with Visikol. IHC prior to clearing with Visikol allows labeling of antigendistribution in whole tissues with microscopic techniques, eliminating the need for sectioning, reconstruction, and stereology.

Mouse brain

The metatarsals of the mouse can be easily visualized

Fluorescence in situ Hybridization

Fluorescence in situ hybridization (FISH) is a powerful labeling technique to identify mRNA or DNA in tissues. Traditional FISH is limited to thin tissue sections, but with Visikol, tissue-wide gene expression can be accomplished with ease. Visikol coupled to FISH is a powerful tool for study protein distribution in tissues.

Rapid Phenotyping

Using a combination of fluorescent sensors and labels, reporter genes, immunohistochemistry, and fluorescent microscopy in conjunction with Visikol tissue clearing, disease-state tissues can be rapidly phenotyped with ease. Optical clearing techniques have made huge waves in the literature, but none are as easy and safe as Visikol.

Mouse cerebellum - H&E slide.