Quantification of global m6A RNA methylation levels by LC-MS/MS
Epigenetics is the study of heritable changes in gene expression without any alternation in the DNA sequence. The main [...]
Using Cell Painting for Morphological Changes
To understand the cytological profiles of cells, a cell painting assay can be used to identify the difference in [...]
An Example of Multi-Dimensional Image Analysis: Advanced 3D Cell Counting
As multi-dimensional imaging becomes more accessible to many areas of research, the need for 3D analysis has also increased. [...]
Q&A with Justin Burrell, MS, PhD About Visikol HISTO™
How Justin Burrell, MS, PhD from the University of Pennsylvania Studies 3D Cellular Scaffolds Using Visikol HISTO™ Products [...]
Methods of Drug Delivery
Any compound that is a part of the drug discovery process must be assessed for its suitability for [...]
Understanding Blocking Buffers in Immunofluorescence Workflows
Reducing the nonspecific binding of secondary antibodies in immunofluorescence workflows is critical to generating high quality data from tissues [...]
The Importance of Dehydration and Rehydration of Fixed Tissue for Immunolabeling
In order to optimize the quality of microscopic images obtained from Formalin Fixed Paraffin Embedded (FFPE) samples, the starting [...]
How Image Filtering Works
When analyzing images, filters are essential for pre-processing images to make them easier to interpret and analyze. At Visikol, [...]
Our frenemies, RNases
Over the past few decades, the popular scientific view of ribonucleases – aka RNases – has become much richer [...]
Gene-specific methylation analysis by LC-MS/MS
DNA methylation is a critical epigenetic modification that controls gene expression and genome stability, which has oncogenic implications during [...]